GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs17065868 | 1 | rs61947991 | chr13:45128009 | CCDC122 | chr13:44410491-44453826:- | 0.35 | 3.78 | 0.000178 | Antineutrophil cytoplasmic antibody-associated vasculitis |
| THCA | cis | rs4759375 | 1 | rs61953394 | chr12:123753372 | C12orf65 | chr12:123717841-123742481:+ | -0.25 | -4.19 | 3.39E-5 | HDL cholesterol |
| THCA | cis | rs17079247 | 1 | rs61960240 | chr13:85765007 | SLITRK6 | chr13:86366922-86373483:- | -0.22 | -3.91 | 0.000105 | Bipolar disorder (mania) |
| THCA | cis | rs17657012 | 1 | rs61976983 | chr14:55172764 | SAMD4A | chr14:55034637-55260033:+ | -0.38 | -3.82 | 0.000152 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs17657012 | 1 | rs61976985 | chr14:55176593 | SAMD4A | chr14:55034637-55260033:+ | -0.39 | -3.92 | 0.000103 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs17657012 | 1 | rs61976986 | chr14:55176860 | SAMD4A | chr14:55034637-55260033:+ | -0.39 | -3.92 | 0.000103 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs17772222 | 1 | rs61977049 | chr14:88827000 | SPATA7 | chr14:88852012-88904802:+ | -0.17 | -3.58 | 0.000384 | Coronary artery calcification |
| THCA | cis | rs17772222 | 1 | rs61977058 | chr14:88881915 | SPATA7 | chr14:88852012-88904802:+ | -0.18 | -3.82 | 0.000149 | Coronary artery calcification |
| THCA | cis | rs7147624 | 1 | rs61987807 | chr14:66207050 | LOC645431 | chr14:65877313-65879335:- | 0.26 | 3.46 | 0.000592 | Chronic obstructive pulmonary disease-related biomarkers |
| THCA | cis | rs17767392 | 1 | rs61991203 | chr14:71767841 | SIPA1L1 | chr14:71933902-72206118:+ | 0.27 | 5.57 | 4.19E-8 | Mitral valve prolapse |
| THCA | cis | rs17767392 | 1 | rs61991204 | chr14:71768073 | SIPA1L1 | chr14:71933902-72206118:+ | 0.27 | 5.57 | 4.19E-8 | Mitral valve prolapse |
| THCA | cis | rs17767392 | 1 | rs61991205 | chr14:71771921 | SIPA1L1 | chr14:71933902-72206118:+ | 0.27 | 5.56 | 4.45E-8 | Mitral valve prolapse |
| THCA | cis | rs17767392 | 1 | rs61991248 | chr14:71860529 | SIPA1L1 | chr14:71933902-72206118:+ | 0.27 | 5.4 | 1.04E-7 | Mitral valve prolapse |
| THCA | cis | rs17767392 | 1 | rs61991250 | chr14:71869684 | SIPA1L1 | chr14:71933902-72206118:+ | 0.27 | 5.49 | 6.48E-8 | Mitral valve prolapse |
| THCA | cis | rs709400 | 1 | rs61995780 | chr14:104120612 | KLC1 | chr14:104029299-104167887:+ | -0.22 | -4.37 | 1.55E-5 | Body mass index |